Persönliche Daten:

Name: Robert Mandic

Geburtsdatum 28. Mai 1966

Geburtsort: Gütersloh, Nordrhein-Westfalen, Deutschland

1985 – 1992 Humanmedizinstudium an der Philipps Universität Marburg

1992 - 1993 Arzt im Praktikum, Zentrum für Innere Medizin, Klinikum der Philipps Universität Marburg

1994 Approbation als Arzt [Nr.: A 940180] Promotion (magna cum laude) Gastarzt, Stanford University School of Medicine, “Division of Orthopaedic Surgery”, Stanford, USA

1995 United States Medical Licensing Examinations, Steps 1 und 2: ECFMG-Zertifikat erteilt [# 0-518-881-8]

1995 - 1998 Postdoktorand, Stanford University, USA

1998 - 2000 Postdoktorand, University of California, San Francisco, USA

seit 2000 Wissenschaftlicher Mitarbeiter und Leiter des Forschungslabors, Universitäts HNO-Klinik Marburg, UKGM, Standort Marburg

2006 Facharzt für HNO-Heilkunde (3.11.2006) Habilitation für das Fach HNO-Heilkunde (20.12.2006)

2007 Ernennung zum Privatdozenten (9.2.2007)

Förderungen:

Stanford Deans Award, 1996 Alfred und Ursula Kulemann Stiftung 2003, 2004, 2005, 2007 Forschungsförderung gem. § 2 Abs. 3 Kooperationsvertrag 2008

Mitgliedschaften in akademischen Vereinigungen:

American Association for Cancer Research American Society for Cell Biology Deutsche Gesellschaft f. HNO-Heilkunde, Kopf & Halschirurgie Marburg Alumni Association Stanford Alumni Association

Fremd- sprachen:

Englisch, Serbokroatisch

1. Wagner AC, Funck RC, Heymanns J, Mandic R, Maisch B. Anemia with LDH-elevation in a patient with aortic valve replacement. Herz. 1994;19:152-5.
2. Mandic R, Trimble WS, Lowe AW. Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1). Gene. 1997;199:173-9.
3. Mandic R, Lowe AW. Characterization of an alternatively spliced isoform of rat vesicle associated membrane protein-2 (VAMP-2). FEBS Lett. 1999;451:209-13.
4. Mandic R, Fackler OT, Geyer M, Linnemann T, Zheng YH, Peterlin BM. Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity. Mol. Biol. Cell. 2001;12:463-73.
5. Mandic R, Eikelkamp N, Peldszus R, Sadowski M, Sesterhenn AM, Dunne AA, Werner JA. Variations of EGF-R surface expression in squamous cell carcinomas of the head and neck region. Anticancer Res. 2001;21:3413-8.
6. Mandic R, Opper C, Krappe J, Wesemann W. Platelet sialic acid as a potential pathogenic factor in coronary heart disease. Thromb. Res. 2002;106:137-41.
7. Mandic R, Dunne AA, Eikelkamp N, Ramaswamy A, Schulz S, Teymoortash A, Sesterhenn A, Moll R, Werner JA. Expression of MMP-3, MMP-13, TIMP-2 and TIMP-3 in the VX2 carcinoma of the New Zealand white rabbit. Anticancer Res. 2002;22:3281-4.
8. Geyer M, Yu H, Mandic R, Linnemann T, Zheng YH, Fackler OT, Peterlin BM. Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. J Biol Chem. 2002;277:28521-9.
9. Linnemann T, Zheng YH, Mandic R, Peterlin BM. Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV. Virology. 2002;294:246-55.
10. Dunne AA, Mandic R, Ramaswamy A, Plehn S, Schulz S, Lippert BM, Moll R, Werner JA. Lymphogenic metastatic spread of auricular VX2 carcinoma in New Zealand white rabbits. Anticancer Res. 2002;22:3273-9.
11. Mandic R, Lieder A, Sadowski M, Peldszus R, Werner JA. Comparison of surface HLA class I levels in squamous cell carcinoma cell lines of the head and neck. Anticancer Res. 2004;24:973-9.
12. Teymoortash A, Mandic R, Schrader C, Werner JA. Extracellular matrix molecules in chronic obstructive sialadenitis: an immunocytochemical and Western blot investigation. J. Oral. Sci. 2004;46:227-33.
13. Wiegand S, Dünne AA, Müller HH, Mandic R, Barth P, Davis RK, Werner JA. Meta-analysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma. Cancer. 2005,104:94-100.
14. Sesterhenn AM, Mandic R, Dunne AA, Werner JA. Cytokeratins 6 and 16 are frequently expressed in head and neck squamous cell carcinoma cell lines and fresh biopsies, Anticancer Res. 2005;25:2675-80.
15. Dünne AA, Mandic R, Falkenberg S, Dalchow CV, Sesterhenn AM, Werner JA. RT-PCR expression profiling of matrix metalloproteinases and their specific inhibitors in cell lines and fresh biopsies of squamous cell carcinomas of the head and neck. In Vivo. 2005,19:943-8.
16. Mandic R, Teymoortash A, Kann P, Werner JA. Sialadenosis of the major salivary glands in a patient with central diabetes insipidus, treated with antidiuretic hormone - implications of aquaporin water channels in the pathomechanism of sialadenosis. Exp. Clin. Endocrinol. Diabetes. 2005;113:205-7.
17. Mandic R, Ludwig T, Oberleithner H, Werner JA. Evaluation of head and neck squamous cell carcinoma invasiveness by the electrical resistance breakdown assay. Clin. Exp. Metastasis. 2005,21:699-704.
18. Mandic R, Schamberger CJ, Müller JF, Geyer M, Zhu L, Carey TE, Grénman R, Dünne AA, Werner JA. Reduced cisplatin sensitivity of HNSCC cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53. Clin. Cancer Res. 2005,11:6845-52 [selected for journal cover caption].
19. Mandic R, Rodgarkia-Dara CJ, Zhu L, Folz BJ, Bette M, Weihe E, Neubauer A, Werner JA. Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor. FEBS Lett. 2006;580:4793-800.
20. Zhu L, Werner JA, Mandic R. Implications of tropomyosin-related kinase B (TrkB) in head and neck cancer. Anticancer Res. 2007;27(5A):3121-6.
21. Teymoortash A, Sommer F, Mandic R, Schulz S, Bette M, Aumüller G, Werner JA. Intraglandular application of botulinum toxin leads to structural and functional changes in rat acinar cells. Br. J. Pharmacol. 2007;152(1):161-7.
22. Schulz S, Häussler U, Mandic R, Heverhagen JT, Neubauer A, Dünne AA, Werner JA, Weihe E, Bette M. Treatment with ozone/oxygen-pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas. Int. J. Cancer. 2008;122(10):2360-7.
23. Wiegand S, Malidžan B, Rath AE, Makarova G, Sterz C, Meissner W, Bette M, Adamkiewicz J, Müller-Brüsselbach S, Müller S, Werner JA, Mandic R. The rotamase Pin1 is overexpressed, activated and required for survival of head and neck squamous cell carcinomas in vitro, manuscript in revision.
24. Teymoortash A, Müller F, Juricko J, Bieker M, Mandic R, Librizzi D, Höffken H, Pfestroff A, Werner JA. Botulinum toxin prevents radiotherapy-induced salivary gland damage, manuscript submitted.
25. Mandic R, Rodgarkia-Dara CJ, Krohn V, Wiegand S, Grénman R, Werner JA. Cisplatin Resistance of the HNSCC Cell Line UT-SCC-26A can be Overcome by Stimulation of the EGF-Receptor, manuscript submitted.
26. Mandic R, Meissner W, Rüddel J, Werner JA. Expression of p21WAF1/Cip1 in HNSCC cell lines positively correlates with the level of EGFR phosphorylation, manuscript in preparation.
27. da Costa LJ, dos Santos AL, Mandic R, Shaw K, de Aguiar RS, Tanur A, Luciw P; Peterlin BM. Interactions between Nef, GagPol and Alix facilitate SIV replication and progression to AIDS in rhesus macaques, manuscript in preparation.

1. Werner JA, Rathcke IO, Mandic R. The role of matrix metalloproteinases in squamous cell carcinomas of the head and neck. Clin. Exp. Metastasis. 2002;19:275-82.
2. Wiegand S, Eivazi B, Barth PJ, von Rautenfeld DB, Folz BJ, Mandic R, Werner JA. Pathogenesis of lymphangiomas. Virchows Arch. 2008;453:1-8.
3. Werner JA, Eivazi B, Wiegand S, Negm H, Murthum T, Mandic R, Folz BJ. Hemangiomas and Vascular Malformations of the Head and Neck, manuscript in preparation.